Search
Close this search box.

News

Product Categories

Have questions about our products?

Simply fill out the form below and one of our customer service representatives will contact you shortly.

Certificates

Contact Us

Address: Rm 218, Tangxing Digital Bld, #6 Tangxing Rd, Xi’an, Shaanxi, China
Phone: +86 17791258855
Landline: +86 (0)29 81870046
Email: info@rainwoodbio.com

Curcumin – the body’s immune regulator

Novel Coronavirus (2019-NCOV) pneumonia broke out in December 2019 triggered a discussion on consumers\’ immunity, and \”human\’s own immunity is the best doctor\” and \”enhancing immunity\” have also become the popular words.So, the higher the immunity, the better?

The answer is no. Low immunity and high immunity are both harmful to health.If immunity is too low, the human body cannot recognize the invasion of foreign infection source (such as bacteria, virus, etc.) and eliminate it in time.If the immune system is too high, it will damage its own tissues and organs while attacking foreign sources of infection, leading to the emergence of diseases.For example, rheumatoid arthritis, systemic lupus erythematosus, chronic kidney disease, ulcerative colitis, etc., are all caused by excessive immunity.

So it\’s important to have a balanced immunity.Natural plant extracts have the effect of regulating immunity.Today I will introduce the effect of curcumin, the active ingredient in turmeric, in regulating immunity.

Turmeric has a medicinal history dating back 5,000 years and is an important herb in Ayurveda, the Indian yoga and traditional health regimen.Curcumin is a yellow dye obtained from turmeric (CurcumalongaL.). It is the most commonly used spice in Indian cuisine and the main ingredient of curry powder.In the past few decades, curcumin has been shown to be an effective immunomodulator that regulates the activity of T cells, B cells, macrophages, neutral (white) cells, naturally killed cells, and dendritic cells.

Effects of curcumin on T lymphocytes

Studies have shown that curcumin can inhibit the proliferation of human spleen lymphocytes induced by mitotic factor con-a, PHA and PMA.It can also inhibit the proliferation of T lymphocytes stimulated by PMA and anti-CD28 antibody or induced by PHA.However, Li Xinjian et al. found that low-dose curcumin (0 ~ 6.25 mol/L) significantly upregulated con-a induced T lymphocyte proliferation, which peaked at 6.25 mol/L and gradually decreased after 12.5 mogL.And show inhibition.It\’s almost completely inhibited at 100 mol/L.It is suggested that the immunomodulatory effect of curcumin is related to dose.The possible mechanism is associated with inhibition of NF- B activation.

In addition, curcumin has been shown to enhance immunity in cancer therapy.Curcumin has the ability to change the immune balance, which is beneficial to the immune system and restore the immune system mediated elimination of tumors.

Effect of curcumin on B lymphocytes

Curcumin can inhibit the proliferation of mutant lymphocytes.Curcumin showed inhibitory effects in both mouse and human B lymphoma cells in vitro and in mouse B lymphoma animals.

Effect of curcumin on mononuclear macrophages

Curcumin can inhibit the proliferation of macrophages, increase their phagocytosis, and then regulate the proliferation of spleen cells.Curcumin activates macrophages by downregulating Th1 and NO production.

Effect of curcumin on NK cells (naturally killing cells)

Curcumin can affect the immune function of naturalkiller cells (NK cells) and increase the cytotoxicity of NK cells.Kim et al. found that curcumin also increased the death of refractory natural killer/T cell (NKTL) lymphoma cell lines that were resistant to other treatments.

Effects of curcumin on dendritic cells

Dendriticcells.dc are specialized antigen-presenting cells.It can significantly stimulate the proliferation of initial T cells and is the initiator of the body\’s immune response.It plays a unique role in the induction of immune response.

Studies have shown that curcumin treatment can improve the intracellular uptake of DC through mannose-mediated receptor and increase the ability of DC to capture antigens.Further studies showed that curcumin treatment of DC before LPS stimulation completely inhibited lPS-induced MAPK phosphorylation and NF- B nuclear translocation signaling pathways.

It has been mentioned many times that curcumin inhibits the NF- B signaling pathway. How does curcumin inhibit NF- B signaling?

NF- B(positive transcription factor – B) is a family of inducible transcription factor proteins widely found in eukaryotic cells.NF- B plays an important role in immune cell activation,T and B lymphocyte development, cell proliferation and apoptosis.

NF- B is activated mainly by degradation of I B.In addition, NF- B signaling is activated by a variety of activators in vivo and in vitro, such as cytokines, mitogens, environmental and occupational factors, toxic substances, viral or bacterial products, ultraviolet radiation, and oxygen radicals, all of which activate NF- B in different mechanisms.

Curcumin first inhibits the degradation of I B and then inactivates (or inactivates) NF- B, thereby initiating inflammatory and immune responses.

Curcumin inhibits NF- B activity, which in turn directly inhibits the activity of many pro-inflammatory cytokines (e.g., TNF,IL-1,IL-2,IL-6,IL-8, anDIl-12) and down-regulates the mRNA expression of many pro-inflammatory enzymes (e.g., COX,LOX,MMPs,andNOS).In addition, curcumin further enhances the immunogenic response by inhibiting TLRs.

Curcumin in alzheimer\’s disease, multiple sclerosis, cardiovascular disease, diabetes, allergies, asthma, inflammatory bowel disease, rheumatoid arthritis /, renal ischemia, psoriasis, scleroderma play before immune activity, and curcumin is scientifically proved no toxic and side effect to human body, the body\’s largest tolerance: 12 g/day).It is an important direction for further research as a potential immune modulator in immune disorders.

Please click here to learn more about our related product

Curcumin Extract Powder is one of the plant product. Are you worried that you can’t find good Curcumin Extract Powder? From today onwards, you don’t have to worry about that anymore.

Shaanxi Ronchn Biotech is dedicated to the herbal extract industryIn this field not only have rich experience, also have a good reputation. Its aim is to create a health care raw material brand that everyone can rest assured, to solve your choice of trouble!

Similar Posts

Nutritional Benefits of Freeze-Dried Strawberries

Freeze-Dried Strawberries: A Nutrient-Packed Snack Freeze-dried strawberries pack a punch when it comes to nutrition, offering a concentrated source of vitamins and minerals that contribute to overall health. While the freeze-drying process may lead to some

Read More »

Nutritional Benefits of Freeze-Dried Apples

Are Freeze-Dried Apples Healthy? When it comes to healthy snacking, freeze-dried apples emerge as a popular choice. Amidst the plethora of fruit options available, freeze-dried apples offer a convenient and nutritious alternative, brimming with benefits for

Read More »

Exploring the Wonders of Chlorophyll

Chlorophyll, a green pigment abundant in cyanobacteria’s mesosomes and the chloroplasts of algae and plants, plays a pivotal role in the process of photosynthesis. Its name originates from the Greek words for “pale green” and “leaf,”

Read More »

Exploring Chlorophyll’s Diverse Functions

Chlorophyll, the natural pigment found in green plants, plays multifaceted roles essential for both plant vitality and human health. As a vital component facilitating photosynthesis, chlorophyll enables plants to harness solar energy, converting carbon dioxide and

Read More »

Ask For A Quick Quote

We will contact you within 1 working day, please pay attention to the email with the suffix “@rainwoodbio.com”. 

Please tell us the products you need

We will offer you free samples and a certificate of analysis

We will contact you within 1 working day, please pay attention to the email with the suffix “@rainwoodbio.com”.