The main chemical components in fructus cnidii coumarin and volatile oil, and terpene, glycosides, sugar and other compounds, among them, the coumarin compounds is the main element of the play a cnidium monnieri pharmacological effects, have been isolated from cnidium monnieri identified 48 kinds of coumarin compounds, including 22 kinds of simple coumarin, 9 kinds of linear furan coumarin. Among them, 6 coumarins with high content are commonly used for chemical detection and identification.They were Osthole, Imperatorin, Isopimpinellin, Xishhotoxin, Bergaptene and Isoimperatorin, respectively.
Osthole has inhibitory effect on Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, and can also reduce the pathogenicity of Staphylococcus aureus residual strains. It can be used together with matrine to treat trichomonad vaginitis, eczema, psoriasis and so on.
Osthol has an inhibitory effect on Staphylococcus aureus and has a good effect on bacterial inflammation. Osthol combined with baicalin was used to treat pneumonia caused by staphylococcus aureus.
Osthol can inhibit tumor growth in mouse hepatocellular carcinoma model, induce apoptosis of hepatocellular carcinoma cells through multi-target and multi-pathway, and enhance anti-tumor immune response in hepatocellular carcinoma mice. Osthol can also kill nasopharyngeal carcinoma cells, lung cancer cells and cervical cancer cells, and has inhibitory effect on the growth of many tumor cells. It can be used as an aid against cancer.
Osthol can significantly promote the proliferation and differentiation of bone marrow mesenchymal stem cells and osteoblasts, and also significantly increase the expression levels of osteocalcin and alkaline phosphatase, thus promoting bone formation, increasing bone mineral content and bone strength. The effect of osthol on the proliferation and differentiation of osteoblasts depends on the concentration, and the best concentration is between 5* 10-5m-5 *10-4M.In addition, osthol combined with puerarin can synergistically treat bone dysplasia and osteoporosis.
Osthole can promote the synthesis and secretion of androgen in mouse testicular stromal cells by regulating the gene transcription of enzymes and cell membrane and cytoplasm-related receptors during androgen synthesis. It can also increase the content of testosterone, follicle stimulating hormone and luteinizing hormone in serum, and has androgen-like effect and gonadotropin-like effect. In addition, osthol at 40-80μg/mL can effectively alleviate oxidative stress injury caused by H2O2 in ovarian tissue, protect the function of ovarian tissue, and enhance the antioxidant capacity of ovarian tissue.
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