At the earliest time, because the English name of azalea is similar to that of azalea acid, it was translated into Chinese as azalea acid, and this name is still used today. It is widely found in nature, particularly in grains such as wheat, rye, and barley, and has been described as a “natural anti-inflammatory” in grains. In the 1970s, Dr. Maciua Nazaro-Polo discovered azelic acid’s skin-whitening effect while studying the white spots of tinea versicolor caused by the bacterium pityriasis. When a lot of patients are treating chloasma, acne imprint, discover the original blain to subside gradually, pore become fine, and the amount of oil that the skin secrete is decrescent also, this makes another effect of du diacid — resist inflammation to inhibit adiposity to become the focus that scholars pay attention to.
At present in the study of azelaic acid, mainly concentrated in the anti-inflammatory, containment, suppression black plain synthesis of these three aspects, it’s acne, spot, and has its distinctive characteristics: first, it is a broad spectrum of an antibacterial anti-inflammatory agent, for the skin acne propionic acid bacillus, pseudomonas aeruginosa, escherichia coli, staphylococcus aureus have destroy, also provides a benign skin weak acid environment. It inhibits the production of excessive inflammatory intermediates, such as kallikin-releasing enzymes, antimicrobial peptides, oxygen free radicals and some inflammatory cytokines during inflammation.
It can inhibit the transformation of testosterone to dihydrotestosterone so that it can effectively reduce sebum secretion and save an oily face. At the same time, it also has keratin regulation, anti-hair follicle keratosis, and fundamentally reduces the occurrence and development of acne. Especially for acne, foreign randomized single-blind multi-center clinical observation 289 cases of acne treatment,0.05% retinoic acid cream as the control group, the results showed that 20% azelelic acid treatment of acne, and 0.05% retinoic acid, erythema, scaly pruritus rate was significantly lower than retinoic acid.
Azelaic acid can inhibit coning neuraminidase, and reduce melanin cell number of dendrites and active, the most important thing is that this inhibition is highly selective, for healthy cells (including healthy melanocytes) there is no reaction, only has an effect on the active melanin cell, having said that, we have learned, azelaic acid whitening process of spot, carry bright color of skin, Won\’t appear false white spot, pigment excessive desquits uneven phenomenon of this kind of pigment, be very fierce?
Studies have shown that in the treatment of pigmentation diseases, 20% azelaic acid and 4% hydroquinone (hydroquinone) ointment effect is comparable, and significantly better than 2% hydroquinone ointment. Considering the cytotoxicity of hydroquinone cream, long-term use of high concentrations is not recommended. 20% azelaic acid can be considered as a substitute for hydroquinone cream in clinical practice.
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