About Resveratrol
Resveratrol is a polyphenol compound, mainly derived from grapes (red wine), Polygonum cuspidatum, peanuts, mulberries and other plants. Resveratrol has obvious effects on the prevention of tumors, especially hormone-dependent tumors; it is also a chemopreventive agent for reducing platelet aggregation, preventing and treating atherosclerosis and cardiovascular and cerebrovascular diseases; it can also treat osteoporosis and acne. And Alzheimer’s disease has a preventive effect, has antiviral and immunomodulatory effects. It acts on a monomeric anti-aging enzyme in the human body, and then plays a potential role in preventing various age-related diseases and extending life expectancy. Resveratrol has been used for the treatment of inflammation in Asia for hundreds of years. In recent years, the reason why red wine is considered good for health is that grapes contain this substance. This inspiration stems from an event called the “French Paradox”.
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Resveratrol is a polyphenol compound, mainly derived from grapes (red wine), Polygonum cuspidatum, peanuts, mulberries and other plants. Resveratrol has obvious effects on the prevention of tumors, especially hormone-dependent tumors; it is also a chemopreventive agent for reducing platelet aggregation, preventing and treating atherosclerosis and cardiovascular and cerebrovascular diseases; it can also treat osteoporosis and acne. And Alzheimer’s disease has a preventive effect, has antiviral and immunomodulatory effects. It acts on a monomeric anti-aging enzyme in the human body, and then plays a potential role in preventing various age-related diseases and extending life expectancy. Resveratrol has been used for the treatment of inflammation in Asia for hundreds of years. In recent years, the reason why red wine is considered good for health is that grapes contain this substance. This inspiration stems from an event called the “French Paradox”.
French Paradox (French Paradox) was first proposed by an Irish doctor named Sai Mu Er Blair in an academic paper published in 1819: French people love food and consume a lot of high-calorie and high-cholesterol foods in their usual diet. But the chance of getting cardiovascular disease is much lower than that of English-speaking people. So why does this happen? According to the survey, local people often accompany their meals with wine rich in tannins. Red wine contains resveratrol, which can prevent blood clots, reduce inflammation, promote vasodilation and inhibit bacterial reproduction.
Resveratrol is a natural antioxidant that can reduce blood viscosity, inhibit abnormal platelet aggregation, prevent myocardial occlusion and cerebral embolism, protect the hypoxic heart, and can control and lose weight for obese people. It can effectively restore the decrease in cardiac output caused by burns or hemorrhagic shock, and can dilate arteries and improve microcirculation. It can even prevent the occurrence and development of cancer.
In 1998, when Al Mindell of the United States compiled the \”Anti-aging Scripture\”, resveratrol was listed as one of the \”100 most popular and effective anti-aging substances\”.
The Effects of Resveratrol
Fever reduction and analgesic effect
Resveratrol exerts therapeutic effects through a variety of different ways, and has certain antipyretic and analgesic activities. Studies in intact mice and rats have shown that resveratrol can give the gastric mucosa the ability to resist stress ulcers caused by suppressed gastric secretion without affecting blood pressure.
Anti-cancer and anti-mutation effects
Generally speaking, the occurrence of cancer is roughly divided into three stages. One is that the DNA of normal cells is damaged; the other is that cell division accelerates and enters the process of cancerization; and the third is that the tumor deteriorates. Resveratrol has inhibitory and even reversal effects on the three stages of cancer:
- Inhibition of initiation. Reduce the formation of free radicals, induce the increase of phase II pharmacokinetic enzymes, and antagonize the effect of dioxin;
- Inhibit the enhancement effect. Inhibit cyclooxygenase, inhibit catalase;
- Inhibit development. Inhibit cancer cell proliferation, induce cancer cell differentiation, and induce cancer cell apoptosis.
Resveratrol is expected to be an inhibitor of tyrosine protein kinase PTK. Many medical studies have found that resveratrol has an effect on breast cancer, gastric cancer, colon cancer, prostate cancer, leukemia, ovarian cancer, skin cancer and other malignant tumor cells. Both have obvious inhibitory effects. Published in the “Science” magazine, “Grape’s natural product resveratrol anti-cancer activity” paper mentioned that resveratrol can effectively inhibit cell activities related to various cancer processes. As an antioxidant, antimutagenic and anti-inflammatory agent, resveratrol has shown its ability to chemoprevent cancer. It can prevent cell cancer and prevent the spread of malignant tumors. It can also inhibit protein chromine kinase and prevent the function of kinases. Plays an anti-mutagenic effect, and can also inhibit cell inflammation.
Cardiovascular protection
In the folk, Polygonum cuspidatum, a traditional Chinese medicine rich in resveratrol, has long been used to treat and prevent hyperlipidemia and arteriosclerosis. Studies have shown that resveratrol mainly exerts anti-atherosclerosis, prevents coronary heart disease and protects the cardiovascular system from the following aspects:
- Regulating blood lipids;
- Inhibiting platelet aggregation, promoting fibrinolysis, and anti-thrombotic Formation effect;
- Protect vascular endothelium and inhibit the proliferation of endothelial cells;
- Protect vascular smooth machine cells and inhibit their proliferation;
- Anti-leukocyte effect;
- Antagonize the effect of endothelin-1;
- Anti-oxidation of low-density lipoprotein Function.
Prevent heart and liver damage
It was found in animal experiments that resveratrol can inhibit the deposition of triglycerides and cholesterol in the liver. It can also increase the level of aspartate aminotransferase and alanine aminotransferase by inhibiting the lipid peroxidation reaction in the liver of mice. By analyzing these two enzymes in the serum, the diagnostic information of whether the heart and liver are good can be obtained.
Antithrombotic function
Resveratrol can inhibit the synthesis of lipoxygenase, which is found in white blood cells, heart, brain, lungs and spleen. Therefore resveratrol prevents the formation of blood clots in the blood vessels. And after treatment with antihypertensive drugs like clonidine, it can also inhibit platelet aggregation.
Boost immune system activity
Resveratrol can also promote the healing of scalds by strengthening the immune system. Someone has studied the efficacy of resveratrol in restoring suppressed cellular, humoral and non-specific immune functions in scalded mice. The controlled use of resveratrol provides a drug-dependent immunomodulatory effect. Studies on severely burned mice of different degrees show that resveratrol can restore its damaged functions, such as the ability to respond to antigen signals, proliferation, interleukin II synthesis, and antibody synthesis through lymphocytes. After severely burned animals were treated with controlled resveratrol, their neutrophil levels and adhesion rates returned to near normal levels, and their survival time was prolonged.
Anti-oxidant and anti-free radical effect
Resveratrol is a natural antioxidant found in plants. It plays an antioxidant role mainly by scavenging or inhibiting the generation of free radicals, inhibiting lipid peroxidation, and regulating the activity of antioxidant-related enzymes. Most of the polyhydroxy stilbene substances have anti-oxidation and anti-free radical effects.
Resveratrol’s anti-oxidation and decoupling of free radicals and its pharmacological functions affecting the metabolism of arachidonic acid have aroused widespread interest, because these physiological metabolisms involve many physiological diseases closely related to human health, such as atherosclerosis, Alzheimer’s disease, viral hepatitis, gastric ulcer, inflammation and allergic reactions, etc.
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Anti-inflammatory and antibacterial effects
Resveratrol has an inhibitory effect on Staphylococcus aureus, Catacoccus, Escherichia coli, Pseudomonas aeruginosa, and has a strong inhibitory effect on orphan virus, herpes simplex virus, enterovirus, and Coxsackie A and B groups . Resveratrol reduces the adhesion of platelets and changes the activity of platelets during the anti-inflammatory process to achieve anti-inflammatory.
Longevity
A group of scientists in Italian Pizza found through research that resveratrol can help fish live longer. Among the more than 100 fishes in the experiment, 30 were fed a small amount of resveratrol every day, 60 were fed an appropriate amount, and 20 were fed a large amount. As a result, the first group of fish had no effect, and the second group of fish had no effect. The life span has been extended by 27%, and the life span of the third group of fish has been extended by 50%. This is the first time scientists have discovered that resveratrol can also prolong life in vertebrates.
Weight loss and lipid-lowering effect
Because resveratrol has anti-cancer, anti-oxidant, anti-inflammatory, and anti-bacterial effects, it is loved by people. According to the plant source, it is said that French people often drink high-fat content containing resveratrol, so the French crown The incidence of heart disease is lower than that of other western countries. From this information, it can be known that resveratrol can effectively suppress high-fat prevention and treatment. Some countries and regions have used resveratrol and its products as dietary supplements to develop resveratrol.
