Legend has it that during the Qin Dynasty, there was a village in the central Plains suddenly prevalent a strange disease, the diseased body grew a lump of different sizes, itch unbearable. For this strange disease, the local village doctors, even many famous doctors, are helpless, and people can only watch their patients suffer.
Then a sorcerer came to the village, and said that on an island far off the sea there grew an herb to cure the villagers. The leaves of this herb are feather-like and bloom like umbrellas, and bathing with its seeds can cure villagers’ diseases. However, the herb is difficult to harvest because the island is full of poisonous snakes and the herb is often crushed by snakes.
Hearing that there was such a magic herb, several strong men in the village volunteered to collect it and cure the villagers. So they took a boat to the island. On the fifth Dragon Boat Festival in May, they landed on Snake Island and poured realgar wine on poisonous snakes in search of herbs. After many trials and tribulations, there was only one man left. Finally, the strong man brought back two baskets of herbs with which the villagers washed their seeds. They washed it three or five times before they found out. The herb got its name because it was found underneath the snake, like a snake’s bed.
Cnidium cnidium is the dry and mature fruit of the ophidiaceae snake bed. It has strong medicinal properties, bitter and warm, with small toxicity, and it belongs to the kidney meristem. Its effects include killing insects and relieving itching, dispelling wind due to dampness and dampness, warming the kidney and enhancing Yang. Under the cold wet belt, wet bi lumbago; Kidney deficiency impotence, palace cold infertility. “Shen Nong Ben Cao Jing” said: “the main man impotence wet itching, women in the Yin swelling pain, in addition to bi Qi. In modern clinical practice, cnidium is mainly used outside, mainly used in surgery, gynecology and dermatology. Recently, there have been many studies on osthole, the main medicinal ingredient of Osthole. Currently, osthole has a good therapeutic effect in treating cardiovascular and cerebrovascular system, nervous system, endocrine system, immune system and other diseases [2]. Osthole, also known as methoxyparsley, is the highest content of coumarin in Osthole. Pharmacological studies have shown that osthole has anti-arrhythmia, anti-thrombotic, anti-osteoporosis, anti-inflammatory, antioxidant and hormone like effects.
Functions
Reproductive system protection
Based on the “Compendium of Materia Medica” stated in the effect of “warm husband Yang qi, help women Yin Qi”, modern research found that cnidium of Materia Medica is conducive to the repair of reproductive endocrine function. The common cnidium fruit mixed suspension 150 mg/kg and 75 mg/kg of high and low dose of cyclophosphamide lavage treatment of male mice reproductive system damage, found common cnidium fruit vegetable high doses can significantly increase serum levels of testosterone in the immunohistochemical results showed that high dose can increase testicular testosterone receptor myoid cells express percentage, high and low dose can increase the viscera coefficient of seminal vesicle.
Antiasthmatic action of the central nervous system
One of the antiasthmatic mechanisms of cnidium cnidium (containing cnidium) is related to regulating the hypothalamus-pituitary-adrenal cortex system.
Asthma is a kind of chronic and refractory disease, its essence is chronic allergic inflammatory reaction disease of airway. As an inflammatory reactive disease, the occurrence and development of airway inflammation of asthma is based on the continuous stimulation of the airway by the inflammatory response, including inflammatory cytokines, inflammatory mediators and adhesive proteins. Currently, there are no specific drugs. Glucocorticoids, antihistamines and other drugs in western medicine have obvious effect on asthma in acute attack stage and remission stage, but their selectivity is poor and side effects are large. The serum cortisol content of asthmatic rats sensitized by ovoprotein significantly decreased, indicating that asthmatic rats with asthma constitution had dysfunction of the hypothalamus-pituitary-adrenal cortex system, and total coperiod coumarin could achieve the effect of asthma treatment through the intervention of this system.
Fight the symptoms of kidney Yang deficiency
Osthole can significantly increase the serum concentrations of thyroid stimulating hormone, three thyroid hormones T3, rT3, T4, plasma corticosterone (removing bilateral testis) and adrenocorticotropic hormone in rats with kidney-yang deficiency, and improve the symptoms in mice with kidney-yang deficiency and castrated mice.
Anti – postmenopausal osteoporosis in women
As a systemic bone disease, osteoporosis is one of the most common metabolic diseases, characterized by low bone mass and microstructural degeneration of bone tissue, as well as brittle bone and fracture susceptibility [16]. Postmenopausal osteoporosis is a metabolic bone disease caused by loss of bone mass and changes in bone tissue structure due to estrogen deficiency. It is accompanied by large-scale global health problems and can lead to the death of women over the age of 50 due to different bone problems. Bone loss due to postmenopausal osteoporosis accounts for 3% to 5% of annual bone loss and is mainly due to a significant decrease in estrogen levels. The pathogenesis of osteoporosis is the imbalance between osteoblast (OB) mediated bone formation and osteoclast (OC) mediated bone resorption, mainly manifested as decreased bone formation and increased bone resorption. Therefore, increasing bone formation and decreasing bone resorption is one of the classic treatments for osteoporosis.
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